Dimethyl sulfoxide (DMSO) is a potent compound known for treating a wide range of “incurable” musculoskeletal, neurological, infectious, and autoimmune conditions due to its unique properties
DMSO properties also transform cancer care as it causes cells to stop being cancerous, significantly increases the potency of many cancer treatments (hence improving their safety and efficacy), and protects normal tissue from their toxicity
Many natural treatments are also dramatically more effective once mixed with DMSO. Hematoxylin, a common pathology dye, when mixed with DMSO is an incredibly potent cancer therapy which has no toxicity to normal tissue
Despite promising results and minimal side effects, D-hematoxylin faced significant regulatory barriers, with the FDA and medical establishment effectively marginalizing this potentially breakthrough cancer treatment
This article will review the history of this therapy, which cancers it works best against (e.g., leukemias), and the molecular mechanisms that underlie its remarkable effects
*
DMSO is a naturally occurring substance that has a variety of unique properties that have immense therapeutic potential. In turn, thousands of studies show DMSO safely1 treats a wide range of:
Sadly, once the FDA realized the extent to which DMSO would transform medicine, the agency made the decision to erase it from history. As a result, millions of patients whom it helped and the thousands of studies on its therapeutic potential have been largely forgotten. Consider for example, this 1980 60 Minutes program:
.
Watch on X
.
Fortunately, because DMSO is effective for a wide range of conditions, it’s caught on like wildfire over the last six months (e.g., I’ve already received over 2,000 reports of remarkable responses to DMSO, many for a variety of “incurable” conditions).
DMSO and Cancer
Due to the controversy around DMSO, its pioneers chose to downplay its anticancer potential to avoid backlash against “unproven” treatments. As a result, its cancer-fighting properties remain largely unknown. For example, earlier in this series, I presented hundreds of studies that show DMSO:
Some of the most remarkable benefits are seen when DMSO is combined with nontoxic natural cancer therapies (e.g., recently I reviewed the remarkable results obtained from infusing DMSO mixed with baking soda). Unfortunately, since there are almost an endless number of combinations, most have not been tested, and many incredible ones are likely waiting to be discovered.
Note: DMSO combinations can also be applied topically as DMSO transports substances inside the body and deep into cancer cells.
Hematoxylin
Hematoxylin is a powder obtained from the logwood tree, which has been used for centuries as both a dye and a medicinal substance.2 After being adopted by the textile industry, its oxidized form (hematein), in 1830, was discovered to be excellent for staining many components of cells including DNA.3 It has remained one of the primary stains used in pathology ever since (it’s the “H” in H & E stains).
.
.
While we currently use a systematized process to develop drugs (based on their molecular targets), in the past, it was a much more haphazard process that often arose from incorrect assumptions.
For example, the first antibiotic was developed by mixing a substance known to be toxic to bacteria (arsenic)4 with a dye that stained bacterial cell walls under the theory that the dye would allow arsenic to selectively target bacteria.5
After decades of failed attempts were made to replicate this approach, another “antimicrobial” dye was found,6 but before long it was discovered that the antimicrobial agent was not the dye itself but rather a colorless metabolic product of it, sulfanilamide.7
Similarly, one of the most remarkable therapies I know of (Ultraviolet Blood Irradiation) was originally developed under the belief that exposing the entire circulation to UV light would sterilize the bloodstream and hence treat a lethal infection.
This did not work (it killed the test dogs) but before long, the inventor accidentally only irradiated a small fraction of the dog’s blood and got a remarkable results as inputting a small amount of UV light into the circulation transforms human physiology and allows the self-healing capacity of the body to treat a wide range of illnesses (e.g., UVBI is a highly effective treatment for bacterial and viral infections, circulatory disorders and autoimmune diseases).
Hematoxylin likewise follows a similar journey. Eli Jordon Tucker, Jr., M.D. was a highly decorated orthopedic surgeon in Texas who made many critical orthopedic discoveries through bone research he did in his spare time. This required him to purchase cattle bones from a meat packing company, where he observed that many commercial cows had large cancers covering their faces.
Wondering if there was a type of cancer-resisting antibody in those cows, Tucker began administering extracts of their blood to lab rats and mice with cancers and observed anticancer activity for certain types of cancer.
Since it was unclear how much of a change was occurring, Tucker looked for a dye that could stain the tumors, and eventually realized that hematoxylin was the perfect dye because it stained the cancers one color and normal cells another. Unfortunately, hematoxylin had poor solubility (limiting his ability to experiment), so once DMSO (a potent solvent) came into use around 1963, Tucker started using it.
He quickly discovered it could dissolve a very high concentration of hematoxylin and that this mixture selectively stained cancers leaving normal cells unaffected. Most importantly, there was a “marked increase in central necrosis of the neoplasm,” indicating this mixture could potentially eliminate cancers while sparing normal cells.8
Tucker then decided to conduct toxicity studies (initially in dogs) where he found high concentrations of IV DMSO mixed with hematoxylin (D-hematoxylin) had no toxicity to any of the tissues or organs he examined (and did not accumulate in any non-cancerous tissue). Curiously, the mixture he made was four times less toxic than IV DMSO alone (which was already extremely safe).
He then began treating spontaneous cancers in animals (e.g., in horses, dogs and cows), which included terminal cases with massive tumors (e.g., a large-cell lymphosarcoma, a small-cell lymphosarcoma, generalized malignant melanoma, a squamous cell carcinoma) along with an osteogenic sarcoma. In all of these cases, there was a prompt response, and the animal subsequently recovered.
Tucker’s Work
Tucker gradually determined a workable dose for D-hematoxylin and before long was approached by a colleague who had a comatose female patient on the verge of dying from inoperable fibrosarcoma. D-hematoxylin caused her tumor to recede until it could be surgically removed (at which point she had a full recovery).
Encouraged, Tucker treated more patients. Eventually, in 1968,9 he published results from 37 cancer patients: those receiving D-hematoxylin with other treatments saw a 70% improvement rate, compared to just 5% on conventional therapies alone. Younger, less heavily treated patients did best, and topical or IV routes proved most effective.
Tucker’s patients included many dramatic recoveries — like a 3-year-old boy with terminal cancer who lived into his 30s, a woman with aggressive lymphosarcoma cured after a year of infusions and a high-level Exxon executive with advanced colon cancer survived and later accompanied Tucker to the FDA (who despite being astonished by Tucker’s cases nonetheless stonewalled D-hematoxylin).
Despite promising results and minimal side effects the American Cancer Society targeted the therapy10 and Tucker quickly faced a heavy backlash and was expelled from his hospital. Justifiably fearing he’d lose his license, he stopped publishing but continued privately treating desperate patients (often for free).
D-hematoxylin faded from view, with only a few doctors using it quietly over the years. But the stories remain: of lives saved, cancers reversed, and a dedicated doctor who risked everything to offer hope when no one else would.
Note: Andrew Ivy (who was arguably the most influential doctor in America at the end of World War 2),11 like Tucker theorized there must be a factor in the blood which resisted cancer, and eventually came across a isolate (from cows injected with a cancer-causing fungus who’d then recovered) which did just that.
After refusing to sell out to the AMA (who frequently tried to buy out competing therapies), he was blacklisted by both the FDA and AMA, and despite having thousands of compelling and well-documented cases showing it cured cancer, effectively had his entire reputation destroyed because he’d promoted an “unproven cancer cure.”
Hematoxylin Persists
After its initial discovery, DMSO quickly spread across America, attracting many dedicated proponents. Once the FDA tried to shut down the use of DMSO, some of its proponents fought for decades to prevent it from being forgotten.
A few of those (e.g., such as maverick physician William Campbell Douglass) likewise took up D-hematoxylin, and one medical journalist, podiatrist Morton Walker worked with Tucker so that his formula could be preserved in print and continue to help patients into the future.12
One of them, Jim McCann (a maverick Canadian engineer and self-taught healer), starting with a high-dose treatment that saved a man dying of prostate cancer, began experimenting with D-hematoxylin. He eventually had to relocate to Ecuador, where he quietly trained around 20 doctors. Over time, D-hematoxylin became a fixture in Ecuador’s alternative medicine scene, used by as many as 100 doctors.
Years later, an Ecuadorian doctor successfully used DMSO and antibiotics to treat chronic bacterial prostatitis, curing 44 of 45 patients. Inspired by McCann, he began using a similar approach for prostate cancer, mixing hematoxylin with DMSO. The results were so promising, they sparked a 15-year study that continues today.
Note: Both Tucker and the Ecuador team found D-hematoxylin has a very low LD50 (1257.16 mg/kg), which is between 10 to 100 times less toxic than many commonly used cancer drugs.13 Likewise, hematoxylin alone has negligible toxicity.14 As such, other than fevers or chills (which occur when too high of a dose is infused too quickly), no significant side effects (e.g., signs of organ damage) have been observed from D-hematoxylin.
Recent D-Hematoxylin Patients
That project involved treating approximately 85 patients, with the cure rate in patients who had not previously received chemotherapy averaging between 80% to 90%. As such, D-hematoxylin is an excellent cancer treatment, but it is not perfect and will not work for everyone.
The cancers thus far found to have a good response to D-hematoxylin (some of which are otherwise extremely difficult to treat) included:
Additionally, if a cancer marker is associated with the tumor (e.g., CEA15 or PSA)16 it will often drop rapidly, making it easy to track the progress of D-hematoxylin.
Note: There can be an initial increase in the tumor marker (due to the cancer breaking down and releasing its components to the bloodstream), but this quickly goes down.
As the following cases show, many of the improvements were quite profound:
.
.
.
.
Likewise, similar bone marrow changes were seen in her:
.
.
.
.
Likewise, another bile duct cancer patient had a dramatic improvement in her tumor markers following D-hematoxylin:
.
.
.
.
Note: Her remarkable CT changes can be viewed here.
.
.
Additionally, video footage shows prior to her treatment she was very frail and had difficulty walking, while after 31 days of treatment, she had no difficulty walking and looked vibrant and robust.
Note: Four years later, she had a healthy pregnancy (despite local hematologists having erroneously forecasted she would have issues including becoming severely anemic).
Additionally these patients showed:
How Does D-Hematoxylin Work?
While DMSO has many anticancer properties, they are not sufficient to explain the rapid changes observed. However, a few clues hint at why this combination works:
.
.
Furthermore, these changes continued after D-hematoxylin was stopped, suggesting it initiates a degenerative process in tumors.
Note: Oral D-hematoxylin, while less potent, also displayed these anticancer properties.
.
.
Protein Kinase CK2
Protein Kinase CK2,20 when dysregulated, has been implicated in hundreds of diseases,21 including viral infections such as COVID-19, autoimmune diseases, and neurological conditions. Of those, it’s best known for playing a key role in cancer (e.g., its activity is often elevated in various cancers, which contributes to tumor progression and poor prognosis).
Hematein in turn, has been shown to inhibit CK2 with a high degree of selectivity22,23,24 via binding to a subunit that is over expressed in many cancers,25,26,27 correlates with a poor prognosis,28,29 and when inhibited, causes cancer cells to undergo programmed cell death.30,31
Multiple studies have shown that hematein has selective antitumor effects and can trigger programmed cell death in cancers.32,33,34,35 Additionally, like D-hematoxylin, CK2 inhibitors have also been shown to increase the sensitivity of cancers to chemotherapy.36,37
Finally, most of the cancers which are highly susceptible to D-hematoxylin are also highly dependent on CK2 (particularly blood cancers38,39 — which CK2 inhibitors have repeatedly demonstrated efficacy against40,41,42). Likewise, cells losing their attachment to the extracellular matrix (which DMSO and hematoxylin were shown above to dissolve) triggers a form of cell death (anoikis43), which CK2 confers resistance to in cancer cells.44
As such, it is likely CK2 plays a pivotal role in D-hematoxylin’s anticancer properties and it is plausible that in addition to DMSO potentiating hematoxylin, hematoxylin is also potentiating DMSO’s anticancer properties.
Note: The other potential mechanisms for D-hematoxylin’s anticancer properties we have identified are discussed here.
Conclusion
Over the last century, many promising cancer cures have been discovered but then forgotten due to the medical industry’s hostility towards anything that threatens the cancer monopoly. Having looked through many, D-hematoxylin in particular stands out for its high degree of efficacy, which is immensely fortunate, as unlike many of those other forgotten therapies, by virtue of it being composed of two simple and widely available chemicals, it is still readily accessible.
As such, I am immensely grateful to all of the people who, for the last fifty years, worked tirelessly to preserve Dr. Tucker’s discovery and I believe the MAHA movement will be the time when these Forgotten Sides of Medicine will at last be able to emerge.
Author’s Note: This is an abridged version of a longer article which goes into more detail on all of the data on D-hematoxylin, the existing protocols for its use and how to locate one of the doctors currently providing D-hematoxylin. That article, along with guidelines for general DMSO use can be read here. Additionally, a companion article detailing DMSO’s anticancer properties and the other cancer therapies it enhances can be read here.
*
Click the share button below to email/forward this article. Follow us on Instagram and X and subscribe to our Telegram Channel. Feel free to repost Global Research articles with proper attribution.
A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate AMD’s exceptional insight on a wide range of topics and am grateful to share it. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.
Notes
1 The Forgotten Side of Medicine, October 12, 2024
2, 3 Biotech Histochem. 2005 Mar-Apr;80(2):73-8
4 Wikipedia, Arsphenamine
5 Amazon, The Drug Hunters: The Improbable Quest to Discover New Medicines
6 Wikipedia, Prontosil
7 Wikipedia, Sulfanilamide
8, 9 Int Surg. 1968 Jun;49(6):516-27
10 A Cancer Journal for Clinicians, 21(6), 386-387
11 The Forgotten Side of Medicine, October 27, 2024
12 Amazon, Dmso: Nature’s Healer Dmso
13, 17 The Forgotten Side of Medicine, April 12, 2025
14 Mayer’s Hematoxylin, Accessed May 2025
15 Wikipedia, Carcinoembryonic antigen
16 Wikipedia, Prostate cancer
18 Wikipedia, Hematein
19 Wikipedia, Autolysis (biology)
20 Wikipedia, Casein kinase 2
21, 31 Signal Transduction and Targeted Therapy volume 6, Article number: 183 (2021)
22 International Journal of Oncology 43.5 (2013): 1517-1522
23, 33, 34 Int J Oncol. 2013 Sep 4;43(5):1517–1522
24, 32, 35 BMC Cancer. 2009 May 6;9:135
25, 28 Eur J Cancer. 2011 Mar;47(5):792-801
26, 30 Mol Cancer Res (2004) 2 (12): 712–721
27, 29 Oncotarget. 2015 Sep 25;6(33):34800–34817
36, 42 Cancers (Basel). 2021 Mar 5;13(5):1127
37, 39 Leukemia, Volume 32, Pages 1–10 (2018)
38, 40 Front Pharmacol. 2015 Mar 31;6:70
41 Cancers (Basel). 2023 Jul 21;15(14):3711
43 Wikipedia, Anoikis
44 Mol Cancer Res (2012) 10 (8): 1032–1038
Featured image source
Global Research is a reader-funded media. We do not accept any funding from corporations or governments. Help us stay afloat. Click the image below to make a one-time or recurring donation.
Comment on Global Research Articles on our Facebook page
Become a Member of Global Research
Source link