A new study published in the Journal of Xenobiotics has revealed that parents with high chemical intolerance are nearly six times more likely to have children diagnosed with autism and more than twice as likely to have children diagnosed with attention deficit hyperactivity disorder (ADHD).
The study, which replicates findings from a similar study in 2015, shows higher odds ratios than before. Mothers with chemical intolerance now have 5.29 and 3.18 times the odds of having a child with autism (up from 3.01) and ADHD (up from 2.3), respectively. The increase likely stems from heightened environmental toxin exposure, expanding diagnostic criteria and cumulative chemical burdens. The study also revealed a high autism prevalence of 12.3 percent among participants, much higher than the reported 1 in 36 by the Centers for Disease Control and Prevention.
According to research scientist and author James Lyons-Weiler, Ph.D., this rise is attributed to factors such as immune system dysregulation caused by chemical exposures and adjuvants like aluminum in vaccines.
"A combination of increased environmental toxicant exposures, expanding diagnostic criteria and increased exposure to myriad corporate toxins that induce cell death via ER stress [endoplasmic reticulum stress] and the unfolded protein response. The contribution of an expanded vaccination schedule, particularly involving adjuvants like aluminum, is known to be an environmental cause of ER stress and cell death and thus has neurotoxic, neurodevelopmental and immunomodulatory effects," Lyons-Weiler said.
The study also identified mast cells -- immune cells in connective tissue -- as a potential agent for chemical intolerance. This intolerance could be triggered by fossil fuel derivatives, pesticides, antibiotics and biogenic toxicants like toxic mold and algae.
Mast cells can undergo gene activation or deactivation, with effects transmitted across generations. This process, called Toxicant-Induced Loss of Tolerance, involves initial exposure to toxicants followed by triggering symptoms after subsequent exposures.
"The study's authors appropriately highlight environmental toxicants as key contributors but avoid injected toxicants like mercury and aluminum in their discussion, despite the past studies in which these compounds are also shown to cause ER stress and cell death. They could have further emphasized the role of cumulative and synergistic effects among the various classes of factors: the more toxicants kids are exposed to, the fewer vaccines they can handle and vice versa," Lyons-Weiler said.
Moreover, the study links the increase in autism cases to "toxic exposure theory." Dr. Karl Jablonowski, a senior research scientist at Children's Health Defense, described the "dramatically increased exposure to toxins" such as pesticides, plastics, vaccines, pharmaceuticals and off-gassing materials as key contributors. Jablonowski also stressed epigenetics, the study of how environmental factors influence gene expression, as a major paradigm shift in understanding diseases like autism.
Lyons-Weiler warned that as toxicants in the environment increase, genetic predisposition may become less relevant, with all individuals potentially vulnerable. "Though we have our instructions for life in our DNA, how those instructions are used depends on epigenetics. Given the toxic soup we live in, the idea that a toxic exposure event in one generation can affect the genetic expression of future generations is scary."
Experts: Autism is not a purely genetic disorder
Autism experts claim that the study has challenged the long-standing view that autism is purely a genetic disorder.
Biologist Dr. Christina Parks pointed to the focus of the study on immune system dysregulation. She described it as a critical factor in disorders previously considered purely psychological or neurological. "Every day, our bodies have to decide whether to ignore particles we come into contact with or to attack these particles. Repeated chemical exposure can throw the immune system into a frenzy, such that it starts attacking things that it previously tolerated," she said. (Related: NEW STUDY: Autism is not just a neurological condition but a whole system disorder driven by environmental toxins.)
John Gilmore, executive director of the Autism Action Network, echoed this perspective. He stated that autism occurs in genetically vulnerable individuals who are exposed to environmental factors. "We know there is no such thing as a genetic epidemic, which has been the overwhelmingly dominant area of autism causation research. We also know that people with autism are much more likely to come from families with histories of auto-immune disorders."
In line with this, Lyons-Weiler noted that both genetics and environmental toxicants contribute to autism risk, with evidence stressing chemical intolerance's role in neurodevelopmental issues.
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Sources include:
ChildrensHealthDefense.org
MDPI.com
Brighteon.com
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