A pilot trial published in BMC Oral Health in 2025 examined whether probiotic supplementation combined with an anti-inflammatory diet reduces measures of gum disease. Researchers followed 120 women ages 20 to 60 with periodontitis and no other systemic health conditions over six weeks, according to the report reviewed by NaturalHealth365.
Both probiotic groups showed significant improvement in pocket depth and attachment loss, two clinical measures dentists use to track periodontitis. The group that combined the probiotic supplement with the personalized anti-inflammatory diet recorded the strongest results, the report stated.
Study Design and Findings
Participants were assigned to one of three groups. One group received standard care alone, one received standard care plus a probiotic supplement and one received standard care plus the supplement combined with a personalized anti-inflammatory diet. The diet emphasized vegetables, whole grains, legumes, olive oil, walnuts, yogurt and kefir, according to the report.
After six weeks, the two probiotic groups showed greater improvement than the standard-care group on both measured outcomes. Researchers described the added improvement in the diet group as an additive effect, according to the report. Dietary patterns high in fermented foods have previously been tied to increased gut microbiome diversity and lower levels of inflammatory proteins in
